ea0092op-09-03 | Oral Session 9: Thyroid Eye Disease | ETA2023
Gulbins Anne
, Horstmann Mareike
, Daser Anke
, Flogel Ulrich
, Oeverhaus Michael
, Bechrakis Nikolaos
, Paul Banga J
, Keitsch Simone
, Wilker Barbara
, Krause Gerd
, Hammer Gary
, Spencer Andy
, Zeidan Ryan
, Eckstein Anja
, Philipp Svenja
, Gortz Gina-Eva
Study objective: We investigated the effect of linsitinib, a dual small-molecule kinase inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) and the Insulin receptor (IR), on Graves Disease and thyroid eye disease. Graves disease (GD), also known as Basedows disease, is the most common cause for hyperthyroidism, typically presenting in patients between 40-60 years. GD is an autoimmune condition of the thyroid which is caused by autoanti...